I'm a little late with this reply, but nevertheless...
I have two .45 Bisleys, one Vaquero and one Accusport, both with 5-1/2" barrels. Both fit my (large) hands well, but the Vaquero feels better balanced; the Accusport seems a little top heavy.
They don't roll in your hand like Blackhawks with XR3-RED (or the 50 year Flattops with the "new" XR-3) grips do. The pinky fits around the grip, not under it.
I personally like the way Bisleys look, even in a CAS holster. YMMV.