you can keep the bore and feed ramp clean without disassembling. you may have to clean the extractor groove after awhile if you start getting extraction or ejection problems. when I was on a pistol team, we only cleaned ours thoroughly once a year; unless something broke, which was pretty rare. After each thorough cleaning, the pistols had to be 'shot in' again, and would usually return to a slightly different zero than before. When you have .45s that are easily capable of keeping all shots in the X-ring at 25 yards, you soon learn what works and what doesn't. baths don't work. do keep the bore and feed ramp clean tho. also, keep it well-lubed. wiping off excess lube is all the cleaning you will generally need.
most people on this forum know that .45 ACP barrels have very shallow rifling. you should examine a new bore at your first opportunity to see just how shallow. that will keep you from thinking you need a new barrel when you don't.