44 mag all the way (for me anyway). All the oomph I need for hunting. Factory ammo is more widely available and priced less.
As for guns, I prefer Ruger revolvers. They make great guns for the money.
S&W also makes nice guns, not nice enough for me to pay the extra over the Rugers.
I've come within inches of buying Taurus products several times in the past, always backed out. In researching Taurus guns, it seems that about equal amounts of people get perfect models that last forever while others get lemons that spend more time in the mail than at the range. I'd rather pay a little more and get a revolver with a much lower failure rate.
Freedom Arms makes really nice revolvers, just way out of my price range. Same with Colt.