Probably my S&W 66. Small enough to conceal, light enough to want to carry it, big enough to shoot comfortably, affordable and easy to find ammo, minimally adequate for smaller deer sized game and even small game with wadcutters. An auto is more comfortable for concealed carry but it is difficult to find one with enough "horsepower" for largish game.
I hate to even consider the thought of having only one. It would be a tough call between a 4" S&W M19 or a 6-1/2" Ruger Old Model Blackhawk in .357.
The 19 is a lot nicer to carry, and would work for darn near any purpose..... but you can whip up some 180 grain golly-whompers for that Ruger that would kill the Smith in short order. And, I'm marginally more accurate with the single action.... probably the additional barrel length and sight radius.
I'd rather answer the question.... "If you could have only 16 handguns....."
Well, since right now I only own one handgun and it is a Glock 23, I am going to say....yep...Glock 23. There are other handguns that I want to own as well, but the Glock 23 offers me the best overall option. It is small enough to conceal, large enough to be a duty weapon, reliable, and powerful. I don't know what more you could ask of a handgun.
Interesting thought.....I have several ... of multiple calibers(.32,.38, 9mm, .45) ....
But, if you forced me to choose..... I'll take the WWII Luger my dad brought home after the war. 9mm, dead accurate....just a beautiful piece of work....and after 60+ years still beautiful and reliable... and very special to me !
I'm torn between my Ruger MKI and my SIG P226. The .22s are fun and cheap, and the Ruger is a bloody tank; the SIG is in a serious caliber, as accurate as I'm willing to back up, absurdly reliable...and I can shoot well with it. Only problem is the caliber on mine...so let's say a P226 in 9mm for the plentiful ammo.