[killerb]

There are lever rifles chambered for some of the same cartridges. Marlin makes a .44 Mag and Puma makes some .454, .44, and maybe .480 Ruger. I'm nut sure about .475 Linebaugh. I second the vote for a Ruger Super Redhawk Alaskan. I'd go for the .454 Casull version, you can chamber and shoot less powerful and expensive .45 Colt loads for fun and practice. The S&W 500, even with the snubby barrel is just so freaking huge and heavy, you might as well carry a rifle.

 

[killerb]

Is it going to be a hunting handgun, or just a backup for dangerous critters like bear? Where I am at the only dangerous predators I worry about are meth heads. The 10mm is quite a powerful round for an autoloader when you use the full power stuff. There are some neutered loads out there for it. If I remember the history of it, the FBI used the 10mm briefly. Recoil and muzzle blast were to great and some lower powered loads were developed. It was ditched, but lead to the development of the the .40S&W. I would lean toward a .357 or my 3" .44Mag, but you said autoloader. It depends entirely on intended use and the laws of your state.